Zoledronic acid and teriparatide: better together?

Zoledronic acid and angiogenesis.

To the Editors: In a recent issue of Clinical Cancer Research, Santini and co-workers (1) assert that zoledronic acid (ZA) may inhibit several antiangiogenic-related cascades and its metronomic administration could represent a new potential therapy targeting the endothelial-tumor-stroma behavior. We agree with the authors because better targeting of ZA to cells outside bone could more likely be...

Learning better together

This article addresses collaborative concept learning in a MAS. In a concept learning problem an agent incrementally revises a hypothetical representation of some target concept to keep it consistent with the whole set of examples that it receives from the environment or from other agents. In the program SMILE, this notion of consistency was extended to a group of agents. A surprising experimen...

Zometa, INN-zoledronic acid

Low concentrations of zoledronic acid are better at regulating bone formation and repair.

The purpose of this study was to investigate optimal concentrations of zoledronic acid (ZA) in terms of their effect on the proliferation, differentiation, and mineralization of primary osteoblasts (OBs) and fibroblasts (FBs). Primary OBs and FBs isolated from patients with clinical osteogenesis imperfecta (OI) and developmental dysplasia of the hip (DDH) were treated in vitro with serial conce...

Preserving cultural heritage: Better together!

The Swiss National Library has a mandate to collect, catalogue, store and disseminate the cultural heritage created in Switzerland and abroad by and about the Swiss, both in print and digital. This sounds like a clear enough mission, but dig deeper and this mandate raises all sorts of tough questions. What exactly is cultural heritage? Obviously, it goes far beyond e-books and e-journals of wel...